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siFVII, siADAMTS13, and siLuc have been encapsulated in LNPs that contains possibly ALC-0315 or MC3 given that the ionizable cationic lipid. We injected mice with 1 mg siRNA for every kg system weight (mg/kg) for knockdown experiments, and 5 mg/kg dose for toxicity studies. A dose of one mg/kg siRNA in mice is regular for inducing knockdown of mRNA